NTSR1

Across TCGA pan-cancer cohorts, NTSR1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NTSR1 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NTSR1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NTSR1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

LUAD, KICH, and BRCA are the cancer types where NTSR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.747	0.857	<.001	114	view →
KICH	DFS	Tertile	III,IV	0.233	0.890	.003	55	view →
BRCA	OS	Quartile	II,III,IV	0.865	0.945	<.001	55	view →
UCEC	DFS	Tertile	All	0.856	0.938	.001	34	view →
CESC	DFS	Median	All	0.659	0.818	<.001	34	view →
OV	OS	Median	III,IV	0.263	0.365	.002	34	view →
COAD	DFS	Tertile	All	0.752	0.838	.016	11	view →
UVM	DFS	Quartile	II,III,IV	0.467	0.739	.023	10	view →
LIHC	OS	Tertile	III,IV	0.393	0.700	.009	10	view →
PAAD	DFS	Median	All	0.204	0.362	.015	8	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	6	view →
LGG	OS	Tertile	All	0.767	0.863	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NTSR1–LUAD (OS)

Open the LUAD breakdown →