NTSR1

Across TCGA cell cohorts, NTSR1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NTSR1-associated genes across cancer lineages are SIRPD, TNP1, and WDR72. Each is linked with NTSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTSR1-to-partner and partner-to-NTSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by NTSR1-low versus NTSR1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTSR1→partner) and Y-score (partner→NTSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	1
BLOOD_Leukemia	TNP1 →	+0.083	+3.984	<.001	.006	3	1
BLOOD_Leukemia	WDR72 →	+0.670	+4.036	<.001	<.001	3	1
BLOOD_Leukemia	MTNR1A →	+0.078	+3.561	<.001	<.001	3	1
BLOOD_Leukemia	OR56A5 →	+0.016	+3.984	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SIRPD by NTSR1 expression — LUNG_SCLC

Explore this box plot interactively →