NTRK3

Across TCGA patient cohorts, NTRK3 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTRK3-associated genes across cancer lineages are ATM, Cyclin-B1, and c-Met_pY1235. Each is linked with NTRK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NTRK3-to-partner and partner-to-NTRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NTRK3-low versus NTRK3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK3→partner) and Y-score (partner→NTRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATM →	-0.547	-2.115	<.001	.015	3	4
UCEC	Cyclin-B1 →	+0.568	+3.392	<.001	<.001	3	4
LUSC	c-Met_pY1235 →	+0.065	+2.231	.033	.006	3	3
LUAD	TSC1 →	-0.430	-2.000	<.001	.027	3	3
LUAD	4E-BP1_pT70 →	+0.184	+2.321	.004	.032	3	3
LUAD	4E-BP1 →	+0.304	+1.919	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

ATM by NTRK3 expression — LUAD

Explore this box plot interactively →