NTRK3

Across TCGA pan-cancer cohorts, NTRK3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NTRK3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NTRK3 RNA is repressed in tumor relative to normal tissue. In most cancer types NTRK3 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and COAD are the cancer types where NTRK3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NTRK3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.933	<.001	11	view →
BLCA	Male	All	−1.416	<.001	10	view →
COAD	All	III,IV	−0.323	<.001	10	view →
LUAD	Female	III,IV	−0.692	<.001	9	view →
LUSC	Female	II,III,IV	−0.895	<.001	8	view →
KIRC	Male	II,III,IV	−0.544	<.001	8	view →
READ	All	All	−0.501	<.001	7	view →
UCEC	All	All	−1.364	<.001	6	view →
BRCA	Female	All	−1.051	<.001	6	view →
KIRP	Male	All	−0.765	<.001	6	view →
HNSC	All	II,III,IV	−0.370	<.001	6	view →
THCA	Female	All	+0.722	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NTRK3–KICH

Open the KICH breakdown →