NTRK3

Across TCGA cell cohorts, NTRK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,806 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NTRK3-associated GO terms across cancer lineages are Protein localization to nucleus, Positive regulation of respiratory burst, and Positive regulation of maintenance of sister chromatid cohesion. Each is linked with NTRK3 in more than 5 cancer types. Because this analysis shows association rather than direction, both NTRK3-to-partner and partner-to-NTRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to nucleus grouped by NTRK3-low versus NTRK3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK3→partner) and Y-score (partner→NTRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protein localization to nucleus →	+0.053	+0.841	<.001	<.001	3	6
PANCREAS	Positive regulation of respiratory burst →	-0.108	-0.035	.009	.002	3	6
SKIN	Positive regulation of maintenance of sister chromatid cohesion →	+0.081	+0.503	.001	.009	3	6
SKIN	Positive regulation of maintenance of mitotic sister chromatid cohesion →	+0.081	+0.503	.001	.009	3	6
BLOOD_Lymphoma	Golgi ribbon formation →	+0.061	+0.095	<.001	.007	3	5
SKIN	Neuroligin clustering involved in postsynaptic membrane assembly →	+0.701	+0.463	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,806 associations by consensus.

Protein localization to nucleus by NTRK3 expression — BLOOD_Leukemia

Explore this box plot interactively →