NTRK3

Across TCGA cell cohorts, NTRK3 mutation is significantly associated with the RNA expression of many other genes, with 298 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NTRK3-associated genes across cancer lineages are OR8B8, NCBP2L, and OR8B12. Each is linked with NTRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTRK3-to-partner and partner-to-NTRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B8 grouped by NTRK3-low versus NTRK3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK3→partner) and Y-score (partner→NTRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR8B8 →	+0.046	+5.369	<.001	.004	3	2
SKIN	NCBP2L →	+0.044	+3.347	<.001	.005	3	2
SOFT_TISSUE	OR8B12 →	+0.041	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR10D3 →	+0.081	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2M2 →	+0.018	+4.930	<.001	.008	3	1
SOFT_TISSUE	GAGE12J →	+0.816	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 298 associations by consensus.

OR8B8 by NTRK3 expression — SOFT_TISSUE

Explore this box plot interactively →