Across TCGA cell cohorts, NTRK1 mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NTRK1-associated genes across cancer lineages are OR1L6, TNFRSF10A, and PRAMEF9. Each is linked with NTRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTRK1-to-partner and partner-to-NTRK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTRK1→partner) and Y-score (partner→NTRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	2
LARGE_INTESTINE	TNFRSF10A →	+0.759	+3.386	.003	.001	3	2
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BONE	TEX43 →	+0.076	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	HAO1 →	+0.231	+3.454	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

Exploration

NTRK1 survival (RNA) · tumor vs normal (RNA) · all NTRK1 data types