NTN5

Across TCGA patient cohorts, NTN5 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTN5-associated genes across cancer lineages are MEK1_p_S217_S221, eIF4E, and Ku80. Each is linked with NTN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTN5-to-partner and partner-to-NTN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by NTN5-low versus NTN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTN5→partner) and Y-score (partner→NTN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	-0.360	-2.584	.002	.010	3	2
UCEC	eIF4E →	+0.204	+2.820	.027	.035	3	1
UCEC	Ku80 →	+0.218	+1.598	.034	.044	3	1
UCEC	MAPK_pT202_Y204 →	-0.648	-2.807	.001	.003	3	1
UCEC	MEK1 →	+0.460	+3.459	.003	.005	3	1
UCEC	mTOR_pS2448 →	-0.181	-3.156	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1_p_S217_S221 by NTN5 expression — UCEC

Explore this box plot interactively →