NTN5

Across TCGA pan-cancer cohorts, NTN5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NTN5 data layer compared with 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NTN5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NTN5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

COAD, ACC, and OV are the cancer types where NTN5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.519	0.702	<.001	95	view →
ACC	DFS	Tertile	All	0.342	0.790	<.001	82	view →
OV	OS	Median	All	0.261	0.382	.002	36	view →
BLCA	OS	Quartile	All	0.776	0.606	.004	34	view →
PAAD	OS	Quartile	All	0.579	0.230	.001	31	view →
STAD	OS	Quartile	II,III,IV	0.556	0.220	.007	20	view →
BRCA	DFS	Tertile	IV	0.301	0.724	.010	19	view →
THYM	DFS	Median	II,III,IV	0.917	0.766	.017	18	view →
PRAD	DFS	Median	All	0.819	0.936	<.001	16	view →
HNSC	OS	Median	III,IV	0.810	0.680	.003	15	view →
MESO	DFS	Tertile	III,IV	0.668	0.154	.006	15	view →
LGG	DFS	Quartile	All	0.226	0.478	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NTN5–COAD (OS)

Open the COAD breakdown →