NTN1

Across TCGA patient cohorts, NTN1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTN1-associated genes across cancer lineages are eIF4E, INPP4B, and JNK2. Each is linked with NTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTN1-to-partner and partner-to-NTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NTN1-low versus NTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTN1→partner) and Y-score (partner→NTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.223	+3.013	.019	.018	3	2
UCEC	INPP4B →	-0.336	-3.169	.021	.018	3	2
UCEC	JNK2 →	+0.259	+2.000	.003	.032	3	2
UCEC	Ku80 →	+0.348	+3.820	.001	<.001	3	2
UCEC	Notch1 →	+0.187	+2.000	.003	.032	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.508	-2.459	.012	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by NTN1 expression — UCEC

Explore this box plot interactively →