NTN1

Across TCGA cell cohorts, NTN1 mutation is significantly associated with the RNA expression of many other genes, with 171 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NTN1-associated genes across cancer lineages are BHLHE23, GAGE12J, and OR5H2. Each is linked with NTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTN1-to-partner and partner-to-NTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by NTN1-low versus NTN1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTN1→partner) and Y-score (partner→NTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BHLHE23 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
STOMACH	OR5H2 →	+0.276	+5.285	<.001	.003	3	1
LARGE_INTESTINE	MANBAL →	-0.412	-3.321	.008	.003	3	1
LARGE_INTESTINE	CHMP4B →	-0.628	-3.657	.001	<.001	3	1
LARGE_INTESTINE	ACOT8 →	-0.576	-3.321	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 171 associations by consensus.

BHLHE23 by NTN1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →