NTHL1

Across TCGA patient cohorts, NTHL1 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NTHL1-associated genes across cancer lineages are RN7SL51P, RNU6-1001P, and RNU6-365P. Each is linked with NTHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NTHL1-to-partner and partner-to-NTHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL51P grouped by NTHL1-low versus NTHL1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NTHL1→partner) and Y-score (partner→NTHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL51P →	+0.283	+5.481	<.001	.005	3	2
PRAD	RNU6-1001P →	+0.328	+7.939	<.001	.008	3	2
BLCA	RNU6-365P →	+0.229	+7.640	<.001	.009	3	2
UCEC	RNU6-280P →	+0.307	+4.923	<.001	.002	3	2
UCEC	MTHFD2P3 →	+0.254	+3.474	<.001	.006	3	2
BRCA	RNU6-725P →	+0.761	+5.122	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

RN7SL51P by NTHL1 expression — LUAD

Explore this box plot interactively →