NT5E

Across TCGA patient cohorts, NT5E mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5E-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with NT5E in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5E-to-partner and partner-to-NT5E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NT5E-low versus NT5E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5E→partner) and Y-score (partner→NT5E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.269	-3.584	.026	.002	3	1
UCEC	A-Raf_pS299 →	-0.145	-3.000	.012	.036	3	1
UCEC	FoxM1 →	+0.254	+2.459	.042	.020	3	1
UCEC	Ku80 →	+0.327	+2.472	.004	.011	3	1
UCEC	mTOR_pS2448 →	-0.143	-2.980	.047	.036	3	1
UCEC	p27_pT198 →	+0.116	+3.000	.025	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by NT5E expression — UCEC

Explore this box plot interactively →