NT5E

Across TCGA pan-cancer cohorts, NT5E RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NT5E data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NT5E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NT5E expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

STAD, UVM, and HNSC are the cancer types where NT5E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	All	0.292	0.496	<.001	128	view →
UVM	DFS	Median	All	0.422	0.729	<.001	104	view →
HNSC	OS	Median	III,IV	0.229	0.425	<.001	94	view →
MESO	OS	Tertile	All	0.370	0.667	<.001	84	view →
LUSC	OS	Median	All	0.604	0.746	<.001	54	view →
PAAD	OS	Tertile	All	0.351	0.706	<.001	51	view →
SCLC	DFS	Quartile	II,III,IV	0.315	0.719	<.001	50	view →
KIRC	DFS	Tertile	All	0.852	0.683	.001	39	view →
CESC	DFS	Quartile	All	0.625	0.839	.001	30	view →
UCEC	DFS	Tertile	II,III,IV	0.894	0.768	.005	30	view →
LIHC	OS	Median	All	0.347	0.597	.005	25	view →
ACC	DFS	Tertile	II,III,IV	0.452	0.738	.012	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NT5E–STAD (DFS)

Open the STAD breakdown →