NT5C3B

Across TCGA patient cohorts, NT5C3B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5C3B-associated genes across cancer lineages are Caspase-7-cleavedD198, Acetyl-a-Tubulin-Lys40, and MAPK_pT202_Y204. Each is linked with NT5C3B in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5C3B-to-partner and partner-to-NT5C3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NT5C3B-low versus NT5C3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5C3B→partner) and Y-score (partner→NT5C3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.851	+3.019	.008	.019	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.581	+3.169	.037	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.574	-3.000	.026	.036	3	1
UCEC	MEK1_p_S217_S221 →	-0.298	-3.000	.046	.036	3	1
UCEC	Raptor →	+0.186	+3.169	.025	.020	3	1
UCEC	PDCD4 →	-0.519	-3.169	.044	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by NT5C3B expression — UCEC

Explore this box plot interactively →