NT5C3B

Across TCGA pan-cancer cohorts, NT5C3B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NT5C3B data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher NT5C3B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NT5C3B expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

MESO, KICH, and LIHC are the cancer types where NT5C3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.254	0.552	<.001	120	view →
KICH	OS	Tertile	All	0.505	1.000	<.001	95	view →
LIHC	DFS	Median	All	0.466	0.614	<.001	95	view →
ACC	DFS	Median	II,III,IV	0.230	0.618	<.001	79	view →
SCLC	DFS	Median	III,IV	0.205	0.561	<.001	66	view →
BLCA	OS	Median	All	0.645	0.774	.001	52	view →
KIRP	DFS	Tertile	IV	0.035	0.435	.004	39	view →
PAAD	OS	Median	All	0.521	0.232	<.001	38	view →
LUSC	OS	Median	All	0.731	0.586	<.001	26	view →
CESC	OS	Median	All	0.827	0.920	.006	22	view →
OV	OS	Median	IV	0.501	0.260	.001	22	view →
LUAD	OS	Quartile	II,III,IV	0.332	0.099	.028	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NT5C3B–MESO (OS)

Open the MESO breakdown →