NT5C3A

Across TCGA patient cohorts, NT5C3A mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5C3A-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and JNK2. Each is linked with NT5C3A in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5C3A-to-partner and partner-to-NT5C3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NT5C3A-low versus NT5C3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5C3A→partner) and Y-score (partner→NT5C3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.571	-3.321	.005	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.629	+2.189	.018	.034	3	2
UCEC	JNK2 →	+0.234	+2.000	.009	.032	3	1
UCEC	Notch1 →	+0.212	+3.013	<.001	.018	3	1
UCEC	p27_pT198 →	+0.125	+2.700	.009	.006	3	1
UCEC	p62 Lck ligand →	+0.639	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ATM by NT5C3A expression — UCEC

Explore this box plot interactively →