NT5C3A

Across TCGA pan-cancer cohorts, NT5C3A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NT5C3A data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher NT5C3A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NT5C3A expression acts as an unfavorable survival marker, although some lineages such as THCA and CHOL show a favorable association.

LIHC, ACC, and THCA are the cancer types where NT5C3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.575	0.772	<.001	73	view →
ACC	DFS	Tertile	All	0.248	0.670	<.001	66	view →
THCA	OS	Median	II,III,IV	1.000	0.956	.002	58	view →
LGG	OS	Median	All	0.744	0.874	<.001	45	view →
CHOL	DFS	Tertile	All	0.575	0.201	.001	39	view →
LUAD	OS	Tertile	All	0.280	0.467	<.001	37	view →
MESO	OS	Median	All	0.664	0.440	<.001	36	view →
KICH	DFS	Median	II,III,IV	0.596	0.917	.011	33	view →
BLCA	DFS	Quartile	III,IV	0.436	0.184	.005	23	view →
THYM	DFS	Median	II,III,IV	0.727	0.937	.003	22	view →
ESCA	OS	Median	All	0.625	0.774	.013	20	view →
HNSC	DFS	Median	III,IV	0.605	0.713	.004	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NT5C3A–LIHC (OS)

Open the LIHC breakdown →