NT5C1B-RDH14

Across TCGA patient cohorts, NT5C1B-RDH14 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NT5C1B-RDH14-associated genes across cancer lineages are RN7SKP43, ASB17, and RNU6-1112P. Each is linked with NT5C1B-RDH14 in more than 1 cancer types. Because this analysis shows association rather than direction, both NT5C1B-RDH14-to-partner and partner-to-NT5C1B-RDH14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP43 grouped by NT5C1B-RDH14-low versus NT5C1B-RDH14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NT5C1B-RDH14→partner) and Y-score (partner→NT5C1B-RDH14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SKP43 →	+0.184	+5.151	.004	.007	3	2
UCEC	ASB17 →	+0.433	+4.525	<.001	.005	3	1
LUSC	RNU6-1112P →	+0.520	+5.792	<.001	.003	3	1
LUSC	RNU6-1311P →	+0.641	+5.093	<.001	.008	3	1
LUSC	MPTX1 →	+0.136	+5.093	<.001	.008	3	1
LUSC	RN7SL655P →	+0.189	+5.337	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RN7SKP43 by NT5C1B-RDH14 expression — LUSC

Explore this box plot interactively →