NSUN6

Across TCGA pan-cancer cohorts, NSUN6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NSUN6 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NSUN6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NSUN6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where NSUN6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.933	0.670	.008	13	view →
PDAC	DFS	Quartile	All	0.671	0.359	.015	8	view →
LUAD	DFS	Quartile	II,III,IV	0.334	0.606	.021	8	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	2	view →
HNSC	DFS	Median	II,III,IV	0.717	0.856	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NSUN6–CCRCC (DFS)

Open the CCRCC breakdown →