NSUN6

Across TCGA patient cohorts, NSUN6 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSUN6-associated genes across cancer lineages are ASNS, CD49b, and Notch1. Each is linked with NSUN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN6-to-partner and partner-to-NSUN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NSUN6-low versus NSUN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN6→partner) and Y-score (partner→NSUN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.351	+2.321	.026	.034	3	2
UCEC	CD49b →	-0.379	-2.794	.002	.003	3	2
UCEC	Notch1 →	+0.180	+2.469	.003	.010	3	1
UCEC	PDCD4 →	-0.571	-3.169	.005	.018	3	1
UCEC	Rab25 →	-0.379	-2.807	.008	.003	3	1
UCEC	Tuberin →	+0.316	+2.179	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASNS by NSUN6 expression — UCEC

Explore this box plot interactively →