NSUN5

Across TCGA pan-cancer cohorts, NSUN5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NSUN5 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NSUN5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NSUN5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where NSUN5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.542	0.905	.009	26	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.596	.004	17	view →
PDAC	OS	Median	IV	0.395	0.937	.026	5	view →
OV	DFS	Tertile	All	0.884	0.613	.049	4	view →
GBM	DFS	Tertile	All	0.322	0.510	.048	2	view →
HNSC	DFS	Median	III,IV	0.714	0.886	.037	1	view →
LUAD	DFS	Quartile	II,III,IV	0.986	0.751	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NSUN5–CCRCC (OS)

Open the CCRCC breakdown →