NSRP1

Across TCGA patient cohorts, NSRP1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSRP1-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and FoxM1. Each is linked with NSRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSRP1-to-partner and partner-to-NSRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NSRP1-low versus NSRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSRP1→partner) and Y-score (partner→NSRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.600	-3.321	.003	.009	3	2
UCEC	EGFR_pY1068 →	-0.294	-3.321	.007	.010	3	1
UCEC	FoxM1 →	+0.285	+2.807	.011	.003	3	1
UCEC	Gab2 →	+0.358	+2.807	.021	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.155	-2.794	.035	.003	3	1
UCEC	Ku80 →	+0.210	+2.128	.041	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PDCD4 by NSRP1 expression — UCEC

Explore this box plot interactively →