NSRP1

Across TCGA pan-cancer cohorts, NSRP1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NSRP1 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NSRP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSRP1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

UVM, KIRC, and HNSC are the cancer types where NSRP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.311	0.878	.001	50	view →
KIRC	OS	Median	All	0.713	0.562	<.001	48	view →
HNSC	OS	Median	All	0.596	0.810	<.001	42	view →
ACC	DFS	Tertile	All	0.167	0.729	<.001	42	view →
KIRP	DFS	Median	IV	0.036	0.526	.006	41	view →
MESO	DFS	Quartile	III,IV	0.249	0.442	.004	40	view →
BRCA	DFS	Tertile	III,IV	0.668	0.390	<.001	34	view →
UCS	DFS	Median	IV	0.885	0.440	.015	30	view →
KICH	OS	Median	II,III,IV	0.648	0.958	.006	30	view →
COAD	DFS	Median	All	0.707	0.849	.003	28	view →
LIHC	DFS	Median	All	0.473	0.628	.002	27	view →
CESC	DFS	Quartile	All	0.410	0.724	.010	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NSRP1–UVM (DFS)

Open the UVM breakdown →