NSMCE4A

Across TCGA patient cohorts, NSMCE4A mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMCE4A-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with NSMCE4A in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMCE4A-to-partner and partner-to-NSMCE4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NSMCE4A-low versus NSMCE4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE4A→partner) and Y-score (partner→NSMCE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.136	-2.973	.005	.035	3	1
UCEC	eEF2 →	+0.371	+2.459	.032	.020	3	1
UCEC	EGFR_pY1068 →	-0.383	-3.321	.001	.009	3	1
UCEC	JNK2 →	+0.288	+2.459	.002	.020	3	1
UCEC	MEK1 →	+0.423	+3.169	.016	.019	3	1
UCEC	NDRG1_pT346 →	-0.490	-3.169	.038	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by NSMCE4A expression — UCEC

Explore this box plot interactively →