NSMCE4A

Across TCGA pan-cancer cohorts, NSMCE4A RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NSMCE4A data layer compared with 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NSMCE4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSMCE4A expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

ACC, UVM, and BRCA are the cancer types where NSMCE4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.169	0.744	<.001	128	view →
UVM	DFS	Tertile	II,III,IV	0.299	0.685	.001	89	view →
BRCA	OS	Median	III,IV	0.708	0.414	<.001	70	view →
PRAD	DFS	Median	All	0.704	0.865	.001	28	view →
LIHC	DFS	Median	All	0.461	0.620	<.001	22	view →
BLCA	OS	Quartile	All	0.797	0.624	.003	19	view →
KIRC	DFS	Tertile	IV	0.141	0.382	.018	16	view →
UCEC	OS	Tertile	III,IV	0.883	0.799	.023	12	view →
GBM	DFS	Tertile	All	0.449	0.181	.003	12	view →
HNSC	OS	Median	All	0.817	0.719	.008	11	view →
STAD	DFS	Tertile	IV	0.199	0.557	.045	3	view →
ESCA	OS	Quartile	All	0.466	1.000	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NSMCE4A–ACC (DFS)

Open the ACC breakdown →