NSMCE2

Across TCGA patient cohorts, NSMCE2 mutation is significantly associated with the RNA expression of many other genes, with 1,005 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMCE2-associated genes across cancer lineages are RN7SL123P, RNA5SP411, and RNA5SP412. Each is linked with NSMCE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMCE2-to-partner and partner-to-NSMCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL123P grouped by NSMCE2-low versus NSMCE2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE2→partner) and Y-score (partner→NSMCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL123P →	+0.147	+2.992	.004	.009	3	2
UCEC	RNA5SP411 →	+1.253	+2.393	<.001	.005	3	1
UCEC	RNA5SP412 →	+0.841	+2.481	<.001	.006	3	1
UCEC	CICP28 →	+0.023	+2.866	.002	.002	3	1
UCEC	MIR7845 →	+0.596	+2.352	<.001	.009	3	1
SKCM	TMEM30CP →	+0.121	+4.617	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,005 associations by consensus.

RN7SL123P by NSMCE2 expression — SKCM

Explore this box plot interactively →