NSMCE1

Across TCGA cell cohorts, NSMCE1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NSMCE1-associated genes across cancer lineages are PRM2, MAGEB10, and SIGLECL1. Each is linked with NSMCE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMCE1-to-partner and partner-to-NSMCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM2 grouped by NSMCE1-low versus NSMCE1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE1→partner) and Y-score (partner→NSMCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PRM2 →	+0.035	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	MAGEB10 →	+0.026	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	SIGLECL1 →	+0.027	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	TEX50 →	+0.061	+5.472	<.001	<.001	3	1
LUNG_NSCLC_LUAD	DYTN →	+0.028	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	FAM237A →	+0.196	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PRM2 by NSMCE1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →