NSMCE1-DT

Across TCGA pan-cancer cohorts, NSMCE1-DT RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NSMCE1-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NSMCE1-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NSMCE1-DT expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

KIRC, SKCM, and MESO are the cancer types where NSMCE1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.499	0.698	<.001	115	view →
SKCM	OS	Median	II,III,IV	0.505	0.285	<.001	80	view →
MESO	OS	Median	All	0.653	0.438	<.001	63	view →
COAD	OS	Tertile	All	0.521	0.730	.001	62	view →
BLCA	OS	Median	III,IV	0.752	0.615	.005	30	view →
BRCA	OS	Median	All	0.977	0.948	.003	30	view →
CESC	DFS	Tertile	All	0.624	0.835	.001	24	view →
ACC	DFS	Median	IV	0.595	0.150	.001	24	view →
TGCT	DFS	Median	All	0.929	0.737	<.001	18	view →
PRAD	DFS	Median	All	0.825	0.939	<.001	18	view →
UCS	OS	Tertile	IV	0.761	0.336	.036	12	view →
LIHC	DFS	Tertile	All	0.482	0.599	.025	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NSMCE1-DT–KIRC (DFS)

Open the KIRC breakdown →