NSFL1C

Across TCGA pan-cancer cohorts, NSFL1C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NSFL1C data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NSFL1C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NSFL1C expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

LUAD, BLCA, and LUSC are the cancer types where NSFL1C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.057	0.812	<.001	36	view →
BLCA	DFS	Median	All	1.000	0.329	.031	6	view →
LUSC	OS	Median	All	0.005	0.819	<.001	6	view →
UCEC	DFS	Median	All	0.948	0.622	.046	2	view →
SKCM	DFS	Median	All	0.338	0.640	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NSFL1C–LUAD (OS)

Open the LUAD breakdown →