NSFL1C

Across TCGA pan-cancer cohorts, NSFL1C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NSFL1C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NSFL1C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NSFL1C is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where NSFL1C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NSFL1C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.663	<.001	12	view →
KIRC	All	IV	+0.547	<.001	12	view →
LIHC	Male	II,III,IV	+1.059	<.001	9	view →
STAD	Male	II,III,IV	+0.786	<.001	9	view →
LUSC	Female	All	+0.823	<.001	8	view →
BLCA	Female	III,IV	+0.407	.004	6	view →
CHOL	All	All	+1.727	<.001	5	view →
KICH	Female	All	−0.630	<.001	5	view →
KIRP	All	II,III,IV	+0.476	.019	2	view →
THCA	All	IV	−0.300	.005	2	view →
PRAD	All	All	−0.162	.028	2	view →
ESCA	All	All	+0.679	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NSFL1C–HNSC

Open the HNSC breakdown →