NSFL1C

Across TCGA pan-cancer cohorts, NSFL1C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NSFL1C data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NSFL1C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NSFL1C expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where NSFL1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.917	0.760	.001	30	view →
HNSC	DFS	Median	All	0.746	0.542	.007	13	view →
PDAC	DFS	Quartile	All	0.922	0.705	.005	7	view →
GBM	OS	Quartile	All	0.474	0.265	.026	7	view →
LSCC	DFS	Tertile	All	1.000	0.907	.011	4	view →
CCRCC	DFS	Tertile	III,IV	0.763	1.000	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NSFL1C–LUAD (OS)

Open the LUAD breakdown →