NSFL1C

Across TCGA patient cohorts, NSFL1C mutation is significantly associated with the RNA expression of many other genes, with 1,315 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSFL1C-associated genes across cancer lineages are SNORA36C, RNU6-74P, and RNU6-1082P. Each is linked with NSFL1C in more than 2 cancer types. Because this analysis shows association rather than direction, both NSFL1C-to-partner and partner-to-NSFL1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA36C grouped by NSFL1C-low versus NSFL1C-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSFL1C→partner) and Y-score (partner→NSFL1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNORA36C →	+0.324	+5.038	<.001	.009	3	3
COAD	RNU6-74P →	+0.558	+3.843	<.001	.004	3	2
UCEC	RNU6-1082P →	+0.156	+2.464	.002	.007	3	2
UCEC	RNA5SP473 →	+0.718	+1.770	<.001	.007	3	2
SKCM	MIR425 →	+0.505	+3.551	<.001	.004	3	2
LUSC	RNU6-1064P →	+0.543	+5.337	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,315 associations by consensus.

SNORA36C by NSFL1C expression — LUSC

Explore this box plot interactively →