NSD3

Across TCGA cell cohorts, NSD3 mutation is significantly associated with the mutation status of many other genes, with 2,336 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSD3-associated genes across cancer lineages are RREB1, SEL1L3, and CACNA1E. Each is linked with NSD3 in more than 4 cancer types. Because this analysis shows association rather than direction, both NSD3-to-partner and partner-to-NSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RREB1 grouped by NSD3-low versus NSD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD3→partner) and Y-score (partner→NSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RREB1 →	+1.777	+1.604	.007	.007	1	5
LARGE_INTESTINE	SEL1L3 →	+2.070	+1.669	.007	.007	1	4
STOMACH	CACNA1E →	+2.946	+2.946	.002	.002	1	4
BREAST	CHD7 →	+3.095	+3.558	.008	.008	1	4
LARGE_INTESTINE	FRMPD1 →	+1.874	+2.030	<.001	<.001	1	4
LARGE_INTESTINE	ADARB1 →	+2.263	+1.860	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,336 associations by consensus.

RREB1 by NSD3 expression — LARGE_INTESTINE

Explore this box plot interactively →