NSD2

Across TCGA patient cohorts, NSD2 mutation is significantly associated with the RNA expression of many other genes, with 4,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSD2-associated genes across cancer lineages are MTFP1, PALM, and FBXW5. Each is linked with NSD2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NSD2-to-partner and partner-to-NSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFP1 grouped by NSD2-low versus NSD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD2→partner) and Y-score (partner→NSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTFP1 →	+0.648	+2.039	<.001	<.001	3	4
STAD	PALM →	-1.033	-3.446	.002	.005	3	4
UCEC	FBXW5 →	+0.319	+2.000	.006	.002	3	4
UCEC	CHAF1B →	+0.507	+2.807	<.001	<.001	3	4
UCEC	NUDT2 →	+0.444	+2.280	<.001	<.001	3	4
UCEC	POLR2L →	+0.396	+3.010	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,819 associations by consensus.

MTFP1 by NSD2 expression — UCEC

Explore this box plot interactively →