NSD2

Across TCGA patient cohorts, NSD2 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSD2-associated genes across cancer lineages are PCNA, STAT3_pY705, and FoxM1. Each is linked with NSD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NSD2-to-partner and partner-to-NSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NSD2-low versus NSD2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD2→partner) and Y-score (partner→NSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.402	+3.000	<.001	.034	3	4
UCEC	STAT3_pY705 →	-0.387	-2.201	<.001	<.001	3	4
STAD	FoxM1 →	+0.302	+2.201	.006	.031	3	3
UCEC	Cyclin-B1 →	+0.685	+2.146	<.001	<.001	3	3
UCEC	eEF2 →	+0.375	+3.169	<.001	<.001	3	3
UCEC	ACVRL1 →	-0.110	-1.664	.005	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

PCNA by NSD2 expression — COAD

Explore this box plot interactively →