NSD2

Across TCGA cell cohorts, NSD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,026 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NSD2-associated GO terms across cancer lineages are Mitotic sister chromatid segregation, Chromosome segregation, and Regulation of G2/M transition of mitotic cell cycle. Each is linked with NSD2 in more than 18 cancer types. Because this analysis shows association rather than direction, both NSD2-to-partner and partner-to-NSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid segregation grouped by NSD2-low versus NSD2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD2→partner) and Y-score (partner→NSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid segregation →	+0.128	+1.385	.001	.003	3	19
UPPER_AERODIGESTIVE_TRACT	Chromosome segregation →	+0.111	+1.583	.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.092	+1.402	.002	.001	3	19
SKIN	Regulation of mitotic metaphase/anaphase transition →	+0.116	+1.108	<.001	<.001	3	19
PANCREAS	Microtubule organizing center organization →	+0.095	+1.511	<.001	<.001	3	19
KIDNEY	Positive regulation of cytokinesis →	+0.143	+1.695	<.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,026 associations by consensus.

Mitotic sister chromatid segregation by NSD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →