NRXN2-AS1

Across TCGA pan-cancer cohorts, NRXN2-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NRXN2-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NRXN2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRXN2-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

ACC, BLCA, and UCS are the cancer types where NRXN2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Quartile	All	0.298	0.660	<.001	71	view →
BLCA	DFS	Tertile	All	0.231	0.395	.003	51	view →
UCS	DFS	Quartile	III,IV	0.653	0.101	.003	48	view →
STAD	DFS	Median	All	0.578	0.712	.001	37	view →
KIRC	DFS	Tertile	All	0.755	0.483	<.001	28	view →
OV	DFS	Median	II,III,IV	0.591	0.495	.011	22	view →
UCEC	DFS	Median	All	0.794	0.867	.009	20	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
LIHC	DFS	Tertile	III,IV	0.581	0.314	.024	18	view →
PAAD	OS	Quartile	All	0.720	0.428	.008	17	view →
COAD	DFS	Median	All	0.684	0.833	<.001	17	view →
LUSC	DFS	Quartile	III,IV	0.320	0.878	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NRXN2-AS1–ACC (DFS)

Open the ACC breakdown →