NRXN2-AS1

Across TCGA pan-cancer cohorts, NRXN2-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of NRXN2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NRXN2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRXN2-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where NRXN2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRXN2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.170	.001	10	view →
KICH	Female	III,IV	−0.543	<.001	8	view →
KIRC	Female	All	+0.371	<.001	7	view →
UCEC	All	All	−0.390	<.001	6	view →
CHOL	All	II,III,IV	+0.205	<.001	4	view →
KIRP	Male	III,IV	+0.184	.047	2	view →
THCA	All	All	−0.104	.019	1	view →
STAD	Male	II,III,IV	+0.064	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

NRXN2-AS1–HNSC

Open the HNSC breakdown →