NRSN1

Across TCGA patient cohorts, NRSN1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRSN1-associated genes across cancer lineages are XBP1, EGFR_pY1068, and HSP70. Each is linked with NRSN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRSN1-to-partner and partner-to-NRSN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by NRSN1-low versus NRSN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRSN1→partner) and Y-score (partner→NRSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	XBP1 →	-0.235	-3.312	.022	.010	3	1
UCEC	EGFR_pY1068 →	-0.298	-2.321	.008	.034	3	1
UCEC	HSP70 →	-0.389	-2.000	.031	.032	3	1
UCEC	JNK2 →	+0.273	+3.331	.002	.005	2	2
UCEC	p70-S6K_pT389 →	-0.234	-2.449	.006	.019	3	1
UCEC	Annexin-1 →	+0.758	+2.479	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

XBP1 by NRSN1 expression — LUSC

Explore this box plot interactively →