NRSN1

Across TCGA pan-cancer cohorts, NRSN1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated NRSN1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher NRSN1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NRSN1 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRP show a favorable association.

LGG, KIRP, and KIRC are the cancer types where NRSN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.521	0.252	<.001	54	view →
KIRP	DFS	Quartile	IV	0.865	0.571	.017	28	view →
KIRC	DFS	Quartile	All	0.400	0.691	.005	27	view →
UVM	DFS	Quartile	All	0.401	0.867	.004	27	view →
MESO	OS	Tertile	All	0.298	0.731	.012	24	view →
SCLC	OS	Median	All	0.575	1.000	.004	23	view →
SKCM	OS	Median	All	0.445	0.268	.004	21	view →
ACC	DFS	Tertile	III,IV	0.637	0.191	.013	14	view →
GBM	OS	Tertile	All	0.344	0.497	.009	12	view →
PAAD	DFS	Quartile	All	0.566	0.318	.026	9	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	9	view →
STAD	DFS	Tertile	All	0.463	0.599	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

NRSN1–LGG (DFS)

Open the LGG breakdown →