NRSN1

Across TCGA cell cohorts, NRSN1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NRSN1-associated genes across cancer lineages are ANKRD30BL, FAM9A, and KRT39. Each is linked with NRSN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRSN1-to-partner and partner-to-NRSN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD30BL grouped by NRSN1-low versus NRSN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRSN1→partner) and Y-score (partner→NRSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANKRD30BL →	+0.981	+4.874	<.001	.002	3	1
BLOOD_Leukemia	FAM9A →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRT39 →	+0.108	+4.551	.002	.004	3	1
BLOOD_Leukemia	IZUMO3 →	+0.054	+4.969	<.001	.003	3	1
BLOOD_Leukemia	RNF212B →	+0.056	+4.276	.008	.007	3	1
BLOOD_Leukemia	ZNF705A →	+0.034	+4.392	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ANKRD30BL by NRSN1 expression — BLOOD_Leukemia

Explore this box plot interactively →