NRROS

Across TCGA patient cohorts, NRROS mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRROS-associated genes across cancer lineages are A-Raf_pS299, Cyclin-B1, and HER3. Each is linked with NRROS in more than 2 cancer types. Because this analysis shows association rather than direction, both NRROS-to-partner and partner-to-NRROS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by NRROS-low versus NRROS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRROS→partner) and Y-score (partner→NRROS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.160	-3.459	<.001	.005	3	3
UCEC	Cyclin-B1 →	+0.901	+3.807	<.001	<.001	3	3
SKCM	HER3 →	+0.446	+2.321	.019	.033	3	2
SKCM	Rb_pS807_S811 →	+0.662	+3.700	<.001	.001	3	2
SKCM	VHL →	-0.649	-2.584	.041	.011	3	2
SKCM	CD31 →	-0.173	-3.700	.019	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

A-Raf_pS299 by NRROS expression — UCEC

Explore this box plot interactively →