NRROS

Across TCGA pan-cancer cohorts, NRROS RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NRROS data layer compared with 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NRROS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NRROS expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

HNSC, UVM, and KIRC are the cancer types where NRROS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.749	0.640	<.001	114	view →
UVM	OS	Median	All	0.967	0.737	<.001	78	view →
KIRC	DFS	Tertile	All	0.822	0.504	<.001	72	view →
PAAD	DFS	Median	II,III,IV	0.534	0.366	.004	49	view →
LUAD	OS	Quartile	II,III,IV	0.726	0.392	.003	35	view →
LAML	DFS	Tertile	All	0.682	0.432	.028	16	view →
SARC	OS	Quartile	All	0.820	0.621	.001	14	view →
LUSC	DFS	Quartile	III,IV	0.306	0.935	.009	13	view →
CHOL	DFS	Tertile	All	0.741	0.185	.010	12	view →
UCEC	OS	Median	IV	0.851	0.627	.036	12	view →
THYM	OS	Tertile	All	0.941	0.710	.017	10	view →
STAD	DFS	Quartile	IV	0.087	0.546	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NRROS–HNSC (DFS)

Open the HNSC breakdown →