NRROS

Across TCGA cell cohorts, NRROS mutation is significantly associated with the RNA expression of many other genes, with 451 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRROS-associated genes across cancer lineages are TEX43, C20orf85, and OR1L4. Each is linked with NRROS in more than 2 cancer types. Because this analysis shows association rather than direction, both NRROS-to-partner and partner-to-NRROS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by NRROS-low versus NRROS-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRROS→partner) and Y-score (partner→NRROS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	3
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR51L1 →	+0.036	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR51G2 →	+0.036	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 451 associations by consensus.

TEX43 by NRROS expression — BLOOD_Leukemia

Explore this box plot interactively →