NRP1

Across TCGA pan-cancer cohorts, NRP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NRP1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NRP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NRP1 expression acts as an unfavorable survival marker.

LSCC, PDAC, and UCEC are the cancer types where NRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.715	0.898	.001	47	view →
PDAC	OS	Tertile	All	0.465	0.700	.034	5	view →
UCEC	DFS	Median	II,III,IV	0.477	0.936	.004	4	view →
GBM	DFS	Quartile	All	0.247	0.409	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NRP1–LSCC (OS)

Open the LSCC breakdown →