NRP1

Across TCGA patient cohorts, NRP1 mutation is significantly associated with the RNA expression of many other genes, with 5,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRP1-associated genes across cancer lineages are PBK, EXOSC10, and RAD23A. Each is linked with NRP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NRP1-to-partner and partner-to-NRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by NRP1-low versus NRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRP1→partner) and Y-score (partner→NRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.716	+1.747	<.001	<.001	3	5
UCEC	EXOSC10 →	+0.276	+2.299	.002	<.001	3	4
UCEC	RAD23A →	+0.306	+1.606	.003	<.001	3	4
STAD	ZFYVE19 →	+0.471	+3.195	.001	.009	3	4
UCEC	FLVCR1-DT →	+0.282	+1.480	.003	.006	3	4
UCEC	ZNF616 →	+0.275	+1.668	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,037 associations by consensus.

PBK by NRP1 expression — UCEC

Explore this box plot interactively →