NRP1

Across TCGA patient cohorts, NRP1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRP1-associated genes across cancer lineages are C-Raf, 4E-BP1, and Cyclin-D1. Each is linked with NRP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRP1-to-partner and partner-to-NRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by NRP1-low versus NRP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRP1→partner) and Y-score (partner→NRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	C-Raf →	+0.120	+1.514	.011	.014	3	3
UCEC	4E-BP1 →	+0.252	+1.766	<.001	.003	3	3
STAD	Cyclin-D1 →	-0.427	-3.321	.026	.010	3	2
SKCM	ERK2 →	+0.173	+2.602	.015	.005	3	2
UCEC	eIF4E →	+0.160	+1.920	.005	.008	3	2
UCEC	JNK2 →	+0.190	+1.722	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

C-Raf by NRP1 expression — SKCM

Explore this box plot interactively →