NRN1

Across TCGA cell cohorts, NRN1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible NRN1-associated genes across cancer lineages are CCDC185, C9orf92, and CRYBB1. Each is linked with NRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRN1-to-partner and partner-to-NRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC185 grouped by NRN1-low versus NRN1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRN1→partner) and Y-score (partner→NRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCDC185 →	+0.048	+4.635	<.001	.003	3	1
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
OESOPHAGUS	CRYBB1 →	+0.026	+4.906	<.001	.006	3	1
OESOPHAGUS	KHDRBS2 →	+0.603	+4.906	<.001	.006	3	1
OESOPHAGUS	GPR26 →	+0.036	+4.906	<.001	.006	3	1
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CCDC185 by NRN1 expression — SOFT_TISSUE

Explore this box plot interactively →