NRM

Across TCGA patient cohorts, NRM mutation is significantly associated with the RNA expression of many other genes, with 286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRM-associated genes across cancer lineages are ELOCP18, RNU6-67P, and RN7SKP43. Each is linked with NRM in more than 1 cancer types. Because this analysis shows association rather than direction, both NRM-to-partner and partner-to-NRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOCP18 grouped by NRM-low versus NRM-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRM→partner) and Y-score (partner→NRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ELOCP18 →	+0.346	+4.661	<.001	.004	3	2
SKCM	RNU6-67P →	+0.484	+5.328	<.001	.003	3	2
SKCM	RN7SKP43 →	+0.637	+5.744	<.001	<.001	3	2
UCEC	RNU1-100P →	+0.374	+2.496	.003	.007	3	2
BLCA	GCNT1P2 →	+0.143	+4.973	<.001	.009	3	2
COAD	RNU5A-2P →	+0.368	+6.003	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 286 associations by consensus.

ELOCP18 by NRM expression — SKCM

Explore this box plot interactively →